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Subcellular Organization of the cAMP Signaling Pathway
Manuela Zaccolo, Anna Zerio and Miguel J. Lobo
Christopher Garland, ASSOCIATE EDITOR

Pharmacological Reviews January 2021, 73 (1) 278-309; DOI: https://doi.org/10.1124/pharmrev.120.000086
Open Access
Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms
Antonio Inserra, Danilo De Gregorio and Gabriella Gobbi
Michael Nader, ASSOCIATE EDITOR

Pharmacological Reviews January 2021, 73 (1) 202-277; DOI: https://doi.org/10.1124/pharmrev.120.000056
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Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development
George F. Koob
Robert Dantzer, ASSOCIATE EDITOR

Pharmacological Reviews January 2021, 73 (1) 163-201; DOI: https://doi.org/10.1124/pharmrev.120.000083
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Cognitive Impairment in Older Adults and Therapeutic Strategies
Thomas J. Montine, Syed A. Bukhari and Lon R. White
VIVIAN HOOK, ASSOCIATE EDITOR

Pharmacological Reviews January 2021, 73 (1) 152-162; DOI: https://doi.org/10.1124/pharmrev.120.000031
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Post-Translational Modifications of G Protein–Coupled Receptors Control Cellular Signaling Dynamics in Space and Time
Anand Patwardhan, Norton Cheng and JoAnn Trejo
Gunnar Schulte, ASSOCIATE EDITOR

Pharmacological Reviews January 2021, 73 (1) 120-151; DOI: https://doi.org/10.1124/pharmrev.120.000082
Open Access
Mutations in G Protein–Coupled Receptors: Mechanisms, Pathophysiology and Potential Therapeutic Approaches
Torsten Schöneberg and Ines Liebscher
Paul Insel, ASSOCIATE EDITOR

Pharmacological Reviews January 2021, 73 (1) 89-119; DOI: https://doi.org/10.1124/pharmrev.120.000011
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Pharmacological Manipulation of Translation as a Therapeutic Target for Chronic Pain
Muhammad Saad Yousuf, Stephanie I. Shiers, James J. Sahn and Theodore J. Price
Robert Dantzer, ASSOCIATE EDITOR

Pharmacological Reviews January 2021, 73 (1) 59-88; DOI: https://doi.org/10.1124/pharmrev.120.000030
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E1 Enzymes as Therapeutic Targets in Cancer
Samir H. Barghout and Aaron D. Schimmer
Eric Barker, ASSOCIATE EDITOR

Pharmacological Reviews January 2021, 73 (1) 1-58; DOI: https://doi.org/10.1124/pharmrev.120.000053
Open Access
International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E₂ Receptors (EP1–4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions
Xavier Norel, Yukihiko Sugimoto, Gulsev Ozen, Heba Abdelazeem, Yasmine Amgoud, Amel Bouhadoun, Wesam Bassiouni, Marie Goepp, Salma Mani, Hasanga D. Manikpurage, Amira Senbel, Dan Longrois, Akos Heinemann, Chengcan Yao and Lucie H. Clapp
Eliot H. Ohlstein, ASSOCIATE EDITOR

Pharmacological Reviews October 2020, 72 (4) 910-968; DOI: https://doi.org/10.1124/pr.120.019331
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Development of Novel, Value-Based, Digital Endpoints for Clinical Trials: A Structured Approach Toward Fit-for-Purpose Validation
M. D. Kruizinga, F. E. Stuurman, V. Exadaktylos, R. J. Doll, D. T. Stephenson, G. J. Groeneveld, G. J. A. Driessen and A. F. Cohen
Martin Michel, ASSOCIATE EDITOR

Pharmacological Reviews October 2020, 72 (4) 899-909; DOI: https://doi.org/10.1124/pr.120.000028

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