Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Pharmacological Reviews
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Pharmacological Reviews

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit Pharm Rev on Facebook
  • Follow Pharm Rev on Twitter
  • Follow ASPET on LinkedIn
Review ArticleReview Article

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Michal Heger, Rowan F. van Golen, Mans Broekgaarden and Martin C. Michel
David R. Sibley, ASSOCIATE EDITOR
Pharmacological Reviews January 2014, 66 (1) 222-307; DOI: https://doi.org/10.1124/pr.110.004044
Michal Heger
Department of Experimental Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (M.H., R.F.v.G., M.B.); and Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany (M.C.M.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rowan F. van Golen
Department of Experimental Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (M.H., R.F.v.G., M.B.); and Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany (M.C.M.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mans Broekgaarden
Department of Experimental Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (M.H., R.F.v.G., M.B.); and Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany (M.C.M.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Martin C. Michel
Department of Experimental Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (M.H., R.F.v.G., M.B.); and Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany (M.C.M.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David R. Sibley
Department of Experimental Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (M.H., R.F.v.G., M.B.); and Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany (M.C.M.)
Roles: ASSOCIATE EDITOR
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site

Data Supplement

Files in this Data Supplement:

  • Supplemental Figures S1-S6 -

    Figure S1. The in vitro LC50 concentrations of curcumin for cancers of the reproductive system, plotted as a function of cell line and incubation time.

    Figure S2. The in vitro LC50 concentrations of curcumin for cancers of the digestive system, plotted as a function of cell line and incubation time.

    Figure S3. The in vitro LC50 concentrations of curcumin for cancers of the lymphatic and immune system, plotted as a function of cell line and incubation time.

    Figure S4. The in vitro LC50 concentrations of curcumin for cancers of the nervous system, plotted as a function of cell line and incubation time.

    Figure S5. The in vitro LC50 concentrations of curcumin for cancers of the respiratory system, urinary system, skin, and skeletal system plotted as a function of cell line and incubation time.

    Figure S6. Scatterplot of IC50 values of curcumin plotted as a function of incubation time.

  • Supplemental Table S3.6 -

    Supplemental Table S3.6 Nervous System

  • Supplemental Table S3.7 -

    Supplemental Table S3.7 Skin

  • Supplemental Table S3.8 -

    Supplemental Table S3.8 Skeletal System

  • Supplemental Table S3.9 -

    Supplemental Table S3.9 Urinary System

  • Supplemental Table S3.10 -

    Supplemental Table S3.10 Connective Tissue and Fluids

  • Supplemental Table S1 -

    S1: Summary of curcumin-target molecule interactions on the basis of molecular docking and/or site-directed mutagenesis studies.

  • Supplemental Table S2 -

    Table S2

  • Supplemental Table S3.0 -

    Supplemental Table S3.0 references

  • Supplemental Table S3.1 -

    Supplemental Table S3.1 Reproductive System

  • Supplemental Table S3.2 -

    Supplemental Table S3.2 Lymphatic and Immune System

  • Supplemental Table S3.3 -

    Supplemental Table S3.3 Digestive System

  • Supplemental Table S3.4 -

    Supplemental Table S3.4 Respiratory System

  • Supplemental Table S3.5 -

    Supplemental Table S3.5 Endocrine System

  View article

  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About Pharmacological Reviews
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacology Research & Perspectives
ISSN 1521-0081 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics