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International Union of Basic and Clinical Pharmacology CIV: The Neurobiology of Treatment-resistant Depression: From Antidepressant Classifications to Novel Pharmacological Targets
F. Caraci, F. Calabrese, R. Molteni, L. Bartova, M. Dold, G. M. Leggio, C. Fabbri, J. Mendlewicz, G. Racagni, S. Kasper, M. A. Riva and F. Drago
Eliot H. Ohlstein, ASSOCIATE EDITOR

Pharmacological Reviews July 2018, 70 (3) 475-504; DOI: https://doi.org/10.1124/pr.117.014977
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Genetic Analysis of Rare Human Variants of Regulators of G Protein Signaling Proteins and Their Role in Human Physiology and Disease
Katherine E. Squires, Carolina Montañez-Miranda, Rushika R. Pandya, Matthew P. Torres and John R. Hepler
Alan V. Smrcka, ASSOCIATE EDITOR

Pharmacological Reviews July 2018, 70 (3) 446-474; DOI: https://doi.org/10.1124/pr.117.015354
Open Access
Current Challenges and Opportunities in Treating Glioblastoma
Andrea Shergalis, Armand Bankhead, Urarika Luesakul, Nongnuj Muangsin and Nouri Neamati
Eric L. Barker, ASSOCIATE EDITOR

Pharmacological Reviews July 2018, 70 (3) 412-445; DOI: https://doi.org/10.1124/pr.117.014944
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Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption
Astrid Nehlig
Stephen P. H. Alexander, ASSOCIATE EDITOR

Pharmacological Reviews April 2018, 70 (2) 384-411; DOI: https://doi.org/10.1124/pr.117.014407
Open Access
Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach
Antonio Cuadrado, Gina Manda, Ahmed Hassan, María José Alcaraz, Coral Barbas, Andreas Daiber, Pietro Ghezzi, Rafael León, Manuela G. López, Baldo Oliva, Marta Pajares, Ana I. Rojo, Natalia Robledinos-Antón, Angela M. Valverde, Emre Guney and Harald H. H. W. Schmidt
Martin C. Michel, ASSOCIATE EDITOR

Pharmacological Reviews April 2018, 70 (2) 348-383; DOI: https://doi.org/10.1124/pr.117.014753

About Pharmacological Reviews

Pharmacological Reviews presents important review articles covering the broad spectrum of pharmacological research. Topics covered have included biochemical and cellular pharmacology, drug metabolism and disposition, renal pharmacology, neuropharmacology, behavioral pharmacology, clinical pharmacology, and toxicology. IUPHAR nomenclature reports are published here.

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Pharmacological Reviews is published continuously. Articles are added as they are ready. Quarterly issues are completed on or about the first business day of January, April, July, and October. Check this site for new content or sign up for content alerts.