RT Journal Article SR Electronic T1 RELATIONSHIPS BETWEEN ANTHELMINTIC EFFECTS AND BIOCHEMICAL AND PHYSIOLOGICAL MECHANISMS JF Pharmacological Reviews JO Pharmacol Rev FD American Society for Pharmacology and Experimental Therapeutics SP 871 OP 894 VO 18 IS 1 A1 HOWARD J. SAZ A1 ERNEST BUEDING YR 1966 UL http://pharmrev.aspetjournals.org/content/18/1/871.abstract AB The concept that the selective activity of anthelmintic agents is based on biochemical and physiological differences between the parasite and the host is supported by the results of investigations reviewed in this article. Such differences afford opportunities to design chemical agents that interfere with the functional integrity of the parasite without injury to the host. Up to the present, this possibility has remained a theoretical one, but further advances in our understanding of the physiology and biochemistry of parasitic worms could form the basis for the rational development of more effective and safer anthelmintic drugs. 1966 by The Williams & Wilkins Co.