RT Journal Article
SR Electronic
T1 International Union of Pharmacology. LX. Retinoic Acid Receptors
JF Pharmacological Reviews
JO Pharmacol Rev
FD American Society for Pharmacology and Experimental Therapeutics
SP 712
OP 725
DO 10.1124/pr.58.4.4
VO 58
IS 4
A1 Germain, Pierre
A1 Chambon, Pierre
A1 Eichele, Gregor
A1 Evans, Ronald M.
A1 Lazar, Mitchell A.
A1 Leid, Mark
A1 De Lera, Angel R.
A1 Lotan, Reuben
A1 Mangelsdorf, David J.
A1 Gronemeyer, Hinrich
YR 2006
UL http://pharmrev.aspetjournals.org/content/58/4/712.abstract
AB Retinoid is a term for compounds that bind to and activate retinoic acid receptors (RARα, RARβ, and RARγ), members of the nuclear hormone receptor superfamily. The most important endogenous retinoid is all-trans-retinoic acid. Retinoids regulate a wide variety of essential biological processes, such as vertebrate embryonic morphogenesis and organogenesis, cell growth arrest, differentiation and apoptosis, and homeostasis, as well as their disorders. This review summarizes the considerable amount of knowledge generated on these receptors.