RT Journal Article
SR Electronic
T1 International Union of Pharmacology. LXII. The NR1H and NR1I Receptors: Constitutive Androstane Receptor, Pregnene X Receptor, Farnesoid X Receptor α, Farnesoid X Receptor β, Liver X Receptor α, Liver X Receptor β, and Vitamin D Receptor
JF Pharmacological Reviews
JO Pharmacol Rev
FD American Society for Pharmacology and Experimental Therapeutics
SP 742
OP 759
DO 10.1124/pr.58.4.6
VO 58
IS 4
A1 Moore, David D.
A1 Kato, Shigeaki
A1 Xie, Wen
A1 Mangelsdorf, David J.
A1 Schmidt, Daniel R.
A1 Xiao, Rui
A1 Kliewer, Steven A.
YR 2006
UL http://pharmrev.aspetjournals.org/content/58/4/742.abstract
AB The nuclear receptors of the NR1H and NR1I subgroups include the constitutive androstane receptor, pregnane X receptor, farnesoid X receptors, liver X receptors, and vitamin D receptor. The newly emerging functions of these related receptors are under the control of metabolic pathways, including metabolism of xenobiotics, bile acids, cholesterol, and calcium. This review summarizes results of structural, pharmacologic, and genetic studies of these receptors.