RT Journal Article
SR Electronic
T1 International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the Recognition and Nomenclature of G Protein-Coupled Receptor Heteromultimers
JF Pharmacological Reviews
JO Pharmacol Rev
FD American Society for Pharmacology and Experimental Therapeutics
SP 5
OP 13
DO 10.1124/pr.59.1.5
VO 59
IS 1
A1 Jean-Philippe Pin
A1 Richard Neubig
A1 Michel Bouvier
A1 Lakshmi Devi
A1 Marta Filizola
A1 Jonathan A. Javitch
A1 Martin J. Lohse
A1 Graeme Milligan
A1 Krzysztof Palczewski
A1 Marc Parmentier
A1 Michael Spedding
YR 2007
UL http://pharmrev.aspetjournals.org/content/59/1/5.abstract
AB G protein-coupled receptors (GPCRs) have long been considered to be monomeric membrane proteins. Although numerous recent studies have indicated that GPCRs can form multimeric complexes, the functional and pharmacological consequences of this phenomenon have remained elusive. With the discovery that the functional GABAB receptor is an obligate heterodimer and with the use of energy transfer technologies, it is now accepted that GPCRs can form heteromultimers. In some cases, specific properties of such heteromers not shared by their respective homomers have been reported. Although in most cases these properties have only been observed in heterologous expression systems, there are a few reports describing data consistent with such heteromultimeric GPCR complexes also existing in native tissues. The present article illustrates well-documented examples of such native multimeric complexes, lists a number of recommendations for recognition and acceptance of such multimeric receptors, and gives recommendations for their nomenclature.