TY - JOUR T1 - Gender Differences in the Membrane Transport of Endogenous and Exogenous Compounds JF - Pharmacological Reviews JO - Pharmacol Rev SP - 229 LP - 240 DO - 10.1124/pr.55.2.1 VL - 55 IS - 2 AU - Marilyn E. Morris AU - Hwa-Jeong Lee AU - Lisa M. Predko Y1 - 2003/06/01 UR - http://pharmrev.aspetjournals.org/content/55/2/229.abstract N2 - Gender differences have been well described in pharmacokinetics and contribute to the interindividual variation in drug disposition, therapeutic response, and drug toxicity. Sex-related differences in the membrane transport of endogenous substrates and xenobiotics have been reported in various organs of the body including kidney, liver, intestine, and brain. These gender-related differences in transport systems could also contribute to interindividual variability in pharmacokinetics and pharmacodynamics. This review will focus on current knowledge of gender-associated differences in the transport of endogenous and exogenous compounds in a variety of body organs and will discuss the implications and the clinical significance of these observations. ER -