RT Journal Article SR Electronic T1 Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine JF Pharmacological Reviews JO Pharmacol Rev FD American Society for Pharmacology and Experimental Therapeutics SP 676 OP 814 DO 10.1124/pr.113.008268 VO 66 IS 3 A1 Bernd Nilius A1 Arpad Szallasi A2 David R. Sibley YR 2014 UL http://pharmrev.aspetjournals.org/content/66/3/676.abstract AB The large Trp gene family encodes transient receptor potential (TRP) proteins that form novel cation-selective ion channels. In mammals, 28 Trp channel genes have been identified. TRP proteins exhibit diverse permeation and gating properties and are involved in a plethora of physiologic functions with a strong impact on cellular sensing and signaling pathways. Indeed, mutations in human genes encoding TRP channels, the so-called “TRP channelopathies,” are responsible for a number of hereditary diseases that affect the musculoskeletal, cardiovascular, genitourinary, and nervous systems. This review gives an overview of the functional properties of mammalian TRP channels, describes their roles in acquired and hereditary diseases, and discusses their potential as drug targets for therapeutic intervention.