TY - JOUR T1 - International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors JF - Pharmacological Reviews JO - Pharmacol Rev SP - 338 LP - 367 DO - 10.1124/pr.114.009647 VL - 67 IS - 2 AU - Jörg Hamann AU - Gabriela Aust AU - Demet Araç AU - Felix B. Engel AU - Caroline Formstone AU - Robert Fredriksson AU - Randy A. Hall AU - Breanne L. Harty AU - Christiane Kirchhoff AU - Barbara Knapp AU - Arunkumar Krishnan AU - Ines Liebscher AU - Hsi-Hsien Lin AU - David C. Martinelli AU - Kelly R. Monk AU - Miriam C. Peeters AU - Xianhua Piao AU - Simone Prömel AU - Torsten Schöneberg AU - Thue W. Schwartz AU - Kathleen Singer AU - Martin Stacey AU - Yuri A. Ushkaryov AU - Mario Vallon AU - Uwe Wolfrum AU - Mathew W. Wright AU - Lei Xu AU - Tobias Langenhan AU - Helgi B. Schiöth A2 - Ohlstein, Eliot H. Y1 - 2015/04/01 UR - http://pharmrev.aspetjournals.org/content/67/2/338.abstract N2 - The Adhesion family forms a large branch of the pharmacologically important superfamily of G protein–coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter and a number to denote each subfamily and subtype, respectively. The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98). This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential. ER -