RT Journal Article SR Electronic T1 International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors JF Pharmacological Reviews JO Pharmacol Rev FD American Society for Pharmacology and Experimental Therapeutics SP 338 OP 367 DO 10.1124/pr.114.009647 VO 67 IS 2 A1 Jörg Hamann A1 Gabriela Aust A1 Demet Araç A1 Felix B. Engel A1 Caroline Formstone A1 Robert Fredriksson A1 Randy A. Hall A1 Breanne L. Harty A1 Christiane Kirchhoff A1 Barbara Knapp A1 Arunkumar Krishnan A1 Ines Liebscher A1 Hsi-Hsien Lin A1 David C. Martinelli A1 Kelly R. Monk A1 Miriam C. Peeters A1 Xianhua Piao A1 Simone Prömel A1 Torsten Schöneberg A1 Thue W. Schwartz A1 Kathleen Singer A1 Martin Stacey A1 Yuri A. Ushkaryov A1 Mario Vallon A1 Uwe Wolfrum A1 Mathew W. Wright A1 Lei Xu A1 Tobias Langenhan A1 Helgi B. Schiöth A2 Eliot H. Ohlstein YR 2015 UL http://pharmrev.aspetjournals.org/content/67/2/338.abstract AB The Adhesion family forms a large branch of the pharmacologically important superfamily of G protein–coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter and a number to denote each subfamily and subtype, respectively. The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98). This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.