RT Journal Article SR Electronic T1 International Union of Basic and Clinical Pharmacology. LXXXV: Calcium-Activated Chloride Channels JF Pharmacological Reviews JO Pharmacol Rev FD American Society for Pharmacology and Experimental Therapeutics SP 1 OP 15 DO 10.1124/pr.111.005009 VO 64 IS 1 A1 Fen Huang A1 Xiuming Wong A1 Lily Y. Jan YR 2012 UL http://pharmrev.aspetjournals.org/content/64/1/1.abstract AB Calcium-activated chloride channels (CaCCs) are widely expressed in various tissues and implicated in physiological processes such as sensory transduction, epithelial secretion, and smooth muscle contraction. Transmembrane proteins with unknown function 16 (TMEM16A) has recently been identified as a major component of CaCCs. Detailed molecular analysis of TMEM16A will be needed to understand its structure-function relationships. The role this channel plays in physiological systems remains to be established and is currently a subject of intense investigation.