@article {Watts359, author = {Stephanie W. Watts and Shaun F. Morrison and Robert Patrick Davis and Susan M. Barman}, editor = {Daws, Lynette C.}, title = {Serotonin and Blood Pressure Regulation}, volume = {64}, number = {2}, pages = {359--388}, year = {2012}, doi = {10.1124/pr.111.004697}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {5-Hydroxytryptamine (5-HT; serotonin) was discovered more than 60 years ago as a substance isolated from blood. The neural effects of 5-HT have been well investigated and understood, thanks in part to the pharmacological tools available to dissect the serotonergic system and the development of the frequently prescribed selective serotonin-reuptake inhibitors. By contrast, our understanding of the role of 5-HT in the control and modification of blood pressure pales in comparison. Here we focus on the role of 5-HT in systemic blood pressure control. This review provides an in-depth study of the function and pharmacology of 5-HT in those tissues that can modify blood pressure (blood, vasculature, heart, adrenal gland, kidney, brain), with a focus on the autonomic nervous system that includes mechanisms of action and pharmacology of 5-HT within each system. We compare the change in blood pressure produced in different species by short- and long-term administration of 5-HT or selective serotonin receptor agonists. To further our understanding of the mechanisms through which 5-HT modifies blood pressure, we also describe the blood pressure effects of commonly used drugs that modify the actions of 5-HT. The pharmacology and physiological actions of 5-HT in modifying blood pressure are important, given its involvement in circulatory shock, orthostatic hypotension, serotonin syndrome and hypertension.}, issn = {0031-6997}, URL = {https://pharmrev.aspetjournals.org/content/64/2/359}, eprint = {https://pharmrev.aspetjournals.org/content/64/2/359.full.pdf}, journal = {Pharmacological Reviews} }