PT  - JOURNAL ARTICLE
AU  - Fen Huang
AU  - Xiuming Wong
AU  - Lily Y. Jan
TI  - International Union of Basic and Clinical Pharmacology. LXXXV: Calcium-Activated Chloride Channels
AID  - 10.1124/pr.111.005009
DP  - 2011 Nov 16
TA  - Pharmacological Reviews
PG  - pr.111.005009
4099  - http://pharmrev.aspetjournals.org/content/early/2011/11/14/pr.111.005009.short
4100  - http://pharmrev.aspetjournals.org/content/early/2011/11/14/pr.111.005009.full
AB  - Calcium-activated chloride channels (CaCCs) are widely expressed in various tissues and implicated in physiological processes such as sensory transduction, epithelial secretion, and smooth muscle contraction. Transmembrane proteins with unknown function 16 (TMEM16A) has recently been identified as a major component of CaCCs. Detailed molecular analysis of TMEM16A will be needed to understand its structure-function relationships. The role this channel plays in physiological systems remains to be established and is currently a subject of intense investigation.