PT  - JOURNAL ARTICLE
AU  - Franck Mauvais-Jarvis
AU  - Heiner K. Berthold
AU  - Ilaria Campesi
AU  - Juan-Jesus Carrero
AU  - Santosh Dhakal
AU  - Flavia Franconi
AU  - Ioanna Gouni-Berthold
AU  - Mark L. Heiman
AU  - Alexandra Kautzky-Willer
AU  - Sabra L. Klein
AU  - Anne Murphy
AU  - Vera Regitz-Zagrosek
AU  - Karen Reue
AU  - Joshua B. Rubin
ED  - Barker, Eric
TI  - Sex- and Gender-Based Pharmacological Response to Drugs
AID  - 10.1124/pharmrev.120.000206
DP  - 2021 Apr 01
TA  - Pharmacological Reviews
PG  - 730--762
VI  - 73
IP  - 2
4099  - http://pharmrev.aspetjournals.org/content/73/2/730.short
4100  - http://pharmrev.aspetjournals.org/content/73/2/730.full
SO  - Pharmacol Rev2021 Apr 01; 73
AB  - In humans, the combination of all sex-specific genetic, epigenetic, and hormonal influences of biologic sex produces different in vivo environments for male and female cells. We dissect how these influences of sex modify the pharmacokinetics and pharmacodynamics of multiple drugs and provide examples for common drugs acting on specific organ systems. We also discuss how gender of physicians and patients may influence the therapeutic response to drugs. We aim to highlight sex as a genetic modifier of the pharmacological response to drugs, which should be considered as a necessary step toward precision medicine that will benefit men and women.Significance Statement This study discusses the influences of biologic sex on the pharmacokinetics and pharmacodynamics of drugs and provides examples for common drugs acting on specific organ systems. This study also discusses how gender of physicians and patients influence the therapeutic response to drugs.