RT Journal Article
SR Electronic
T1 Sex- and Gender-Based Pharmacological Response to Drugs
JF Pharmacological Reviews
JO Pharmacol Rev
FD American Society for Pharmacology and Experimental Therapeutics
SP 730
OP 762
DO 10.1124/pharmrev.120.000206
VO 73
IS 2
A1 Franck Mauvais-Jarvis
A1 Heiner K. Berthold
A1 Ilaria Campesi
A1 Juan-Jesus Carrero
A1 Santosh Dhakal
A1 Flavia Franconi
A1 Ioanna Gouni-Berthold
A1 Mark L. Heiman
A1 Alexandra Kautzky-Willer
A1 Sabra L. Klein
A1 Anne Murphy
A1 Vera Regitz-Zagrosek
A1 Karen Reue
A1 Joshua B. Rubin
A2 Eric Barker
YR 2021
UL http://pharmrev.aspetjournals.org/content/73/2/730.abstract
AB In humans, the combination of all sex-specific genetic, epigenetic, and hormonal influences of biologic sex produces different in vivo environments for male and female cells. We dissect how these influences of sex modify the pharmacokinetics and pharmacodynamics of multiple drugs and provide examples for common drugs acting on specific organ systems. We also discuss how gender of physicians and patients may influence the therapeutic response to drugs. We aim to highlight sex as a genetic modifier of the pharmacological response to drugs, which should be considered as a necessary step toward precision medicine that will benefit men and women.Significance Statement This study discusses the influences of biologic sex on the pharmacokinetics and pharmacodynamics of drugs and provides examples for common drugs acting on specific organ systems. This study also discusses how gender of physicians and patients influence the therapeutic response to drugs.