PT  - JOURNAL ARTICLE
AU  - Thomas P. Burris
AU  - Ian Mitchelle S. de Vera
AU  - Isabelle Cote
AU  - Colin A. Flaveny
AU  - Udayanga S. Wanninayake
AU  - Arindam Chatterjee
AU  - John K. Walker
AU  - Nickolas Steinauer
AU  - Jinsong Zhang
AU  - Laurel A. Coons
AU  - Kenneth S. Korach
AU  - Derek W. Cain
AU  - Anthony N. Hollenberg
AU  - Paul Webb
AU  - Douglas Forrest
AU  - Anton M Jetten
AU  - Dean P. Edwards
AU  - Sandra L. Grimm
AU  - Sean Hartig
AU  - Carol A. Lange
AU  - Jennifer K. Richer
AU  - Carol A. Sartorius
AU  - Marc Tetel
AU  - Cyrielle Billon
AU  - Bahaa Elgendy
AU  - Lamees Hegazy
AU  - Kristine Griffett
AU  - Nahuel Peinetti
AU  - Kerry L Burnstein
AU  - Travis S. Hughes
AU  - Sadichha Sitaula
AU  - Keith R. Stayrook
AU  - Alexander Culver
AU  - Meghan H Murray
AU  - Brian N Finck
AU  - John A Cidlowski
TI  - <strong>International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily - Update 2023</strong>
AID  - 10.1124/pharmrev.121.000436
DP  - 2023 Jan 01
TA  - Pharmacological Reviews
PG  - PHARMREV-INR-2021-000436
4099  - http://pharmrev.aspetjournals.org/content/early/2023/08/16/pharmrev.121.000436.short
4100  - http://pharmrev.aspetjournals.org/content/early/2023/08/16/pharmrev.121.000436.full
AB  - The nuclear receptor (NR) superfamily comprises 48 transcription factors in humans that control a plethora of gene network programs involved in a wide range of physiological processes. In this review, we will summarize and discuss recent progress in NR biology and drug development derived from the integration of various approaches, including biophysical techniques, structural studies, and translational investigations. We also highlight how defective NR signaling results in various diseases and disorders and how NRs can be targeted for therapeutic intervention via modulation via binding to synthetic lipophilic ligands. Furthermore, we also review recent studies that improved our understanding of NR structure and signaling. Significance Statement Nuclear receptors are ligand regulated transcription factors that function as key regulators of a wide range of physiological functions. NRs also serve as receptors for myriad drugs and in this review we provide an update of recent research into the function of this family of drug targets.