Transporter | Kinase | Site | References |
---|---|---|---|
Phosphorylation | |||
SERT | PKAa | N- and C-terminal domains | Ramamoorthy et al., 1998a |
PKCa | N- and C-terminal domains | Ramamoorthy et al., 1998a | |
PKGb | Thr276 (IL2) | Ramamoorthy et al., 2007 | |
NET | PKCa | Thr258-Ser259 (IL2) | Jayanthi et al., 2006 |
CamKIIc | C-terminal domain | Uchida et al., 1998 | |
DAT | PKCa | N-terminal Ser cluster (Ser2, Ser4, Ser7, Ser12, Ser13) | Foster et al., 2002; Lin et al., 2003; Granas et al., 2003; Cervinski et al., 2005; Gorentla et al., 2009 |
CamKIIc | N-terminal domain | Fog et al., 2006; Gorentla et al., 2009 | |
ERK1/2a | Thr53 (N-terminal domain) | Gorentla et al., 2009 | |
JNKa | Thr53 (N-terminal domain) | Gorentla et al., 2009 | |
p38 MAPKa | Thr53 (N-terminal domain) | Gorentla et al., 2009 | |
PKAc | N-terminal domain | Gorentla et al., 2009 | |
PKGc | N-terminal domain | Gorentla et al., 2009 | |
CKIIc | N-terminal domain | Gorentla et al., 2009 | |
Cdk5c | N-terminal domain | Gorentla et al., 2009 | |
Aktc | N-terminal domain | Gorentla et al., 2009 | |
GAT1 | Tyr kinasee | Tyr107 (IL1), Tyr317 (IL3) | Whitworth and Quick, 2001 |
N-Linked glycosylation | |||
SERT | Asn208, Asn217 | Rasmussen et al., 2009; Tate and Blakely, 1994 | |
NET | Asn184, Asn192, Asn198 | Melikian et al., 1996; Nguyen and Amara, 1996 | |
DAT | Asn181, Asn188, Asn205 | Li et al., 2004; Torres et al., 2003a | |
GAT1 | Asn176, Asn181, Asn184 | Bennett and Kanner, 1997; Cai et al., 2005 | |
GLYT1 | Asn169, Asn172, Asn182, Asn188 | Olivares et al., 1995 | |
GLYT2 | Asn345, Asn355, Asn360, Asn366 | Martínez-Maza et al., 2001 |
JNK, c-Jun NH2-terminal kinase; CKII, casein kinase II; Cdk5, cyclin-dependent kinase 5.
↵a Phosphorylation of functional transporter, confirmed by in vitro phosphorylation.
↵b Putative. Direct transporter phosphorylation not confirmed.
↵c In vitro phosphorylation only.
d The corresponding residue in human DAT is a Ser.
↵e Phosphorylation of functional transporter, not confirmed by in vitro phosphorylation.