TABLE 8

Potential therapeutic application of EP4 antagonists (inflammation/pain is reviewed in Jones et al., 2009)

AgonistRouteDoseSpeciesExperimental ModelIndicationReference
L 161982Intravitreal injection0.01–1 μMRatO2-retinopathy laser induced choroidal neovascularizationAge-related macular degenerationYanni et al., 2009
ONO-AE2-227In diet100–400 ppmMouseAzoxymethane induced aberrant crypt foci; min mouseColon cancerMutoh et al., 2002
ONO-AE3-208Oral10 mg/kgMouseInjection of M26 cellsColon cancerYang et al., 2006