TABLE 5

Potential therapeutic application of EP₂ agonists

Agonist	Route	Dose	Species	Experimental Model	Indication	Reference
AH 13205	Aerosol	0.1–3 nM	Guinea pigs	Histamine induced bronchoconstriction	Asthma	Nials et al., 1993
Butaprost	Tissue culture vs. oxytocin	10⁻⁶ M infusion	Human	Isolated human uterine specimens from pregnant and nonpregnant donors	Prevention of preterm labor; dysmenorrhoea	Duckworth et al., 2002
Butaprost	Topical (ocular)	0.1%	Monkey	Laser-induced glaucomatous monkey	Glaucoma	Nilsson et al., 2006
CP 533536	Local implant	10, 50, 100 mg/ml	Dog	Canine ulnar critical defect	Fracture healing	Paralkar et al., 2003
CP 533536	Topical (ocular)	0.01–0.1%	Dog, monkey	Laser-induced glaucomatous monkey	Glaucoma	Woodward and Chen, 2007