Table 7

Histamine receptor radioligands

Receptor	Ligand	K_D	Tissue
H₁-receptor	[³H]Mepyramine	0.8 nm	Guinea pig brain^7-a
	[¹²⁵I]Iodobolpyramine	0.1 nm	Guinea pig brain^7-b
	[¹²⁵I]Iodoazidophenpyramine	0.01 nm	Guinea pig cerebellum^7-c
	[¹¹C]Mepyramine	1.0 nm	Human brain (in vivo)^7-d
	[¹¹C]Doxepin	0.1 nm	Human brain (in vivo)^7-e
H₂-receptor	[³H]Tiotidine	25 nm	Guinea pig brain^7-f
	[¹²⁵I]Iodoaminopotentidine	0.3 nm	Guinea pig brain^7-g
	[¹²⁵I]Iodoazidopotentidine	10 nm	Guinea pig brain^7-g
H ₃-receptor	[³H]R-(α)-methylhistamine	0.5 nm	Rat brain^7-h
	[³H]N^α-methylhistamine	2.0 nm	Rat cerebral cortex^7-i
	[¹²⁵I]Iodophenpropit	0.3 nm	Rat cerebral cortex^7-j
	[¹²⁵I]Iodoproxyfan	0.065 nm	Rat striatum^7-k
	[³H]GR168320	0.1 nm	Rat cerebral cortex^7-l

↵7-a Hill et al. (1981)
↵7-b Körner et al. (1986)
↵7-c Ruat et al. (1988)
↵7-d Villemagne et al. (1991)
↵7-e Yanai et al. (1995)
↵7-f Gajtkowski et al. (1983)
↵7-g Ruat et al. (1990a)
↵7-h Arrang et al. (1990)
↵7-i Clark and Hill (1995)
↵7-j Jansen et al. (1992)
↵7-k Ligneau et al. (1994)
↵7-l Brown et al. (1994)