Some of the γ-aminobutyric acidA receptor subtypes in specified rat neurons2-a
Neurons | Subunits | Possible subtypes | ||||
---|---|---|---|---|---|---|
Olfactory bulb | ||||||
Mitral cells | α1 | α3 | β2 | γ2 | ||
Granule cells | α2 | β3 | γ2 | A2a3 | ||
α5 | β3 | γ2 | A5a3 | |||
Short-axon cells | α1 | β2 | γ2 | A1a2 | ||
Periglomerular cells | α2 | α5 | δ | |||
Hippocampus | ||||||
Pyramidal cells | α2 | β3 | γ2 | A2a3 | ||
α5 | β3 | γ2 | A5a3 | |||
Dentate gyrus granule cells | α2 | β3 | γ2 | A2a3 | ||
Most interneurons | α1 | β2 | γ2 | A1a2 | ||
Thalamus | ||||||
Relay neurons | α1 | β2 | γ2 | δ | ||
Reticular nucleus neurons | α3 | γ2 | ||||
Hypothalamus | ||||||
Supraoptic nucleus | α1 | α2 | β2,3 | γ2 | ||
Ventromedial, arcuate nuclei | α2 | β3 | γ2 | A2a3 | ||
α5 | β3 | γ2 | A5a3 | |||
Cerebellum | ||||||
Purkinje cells | α1 | β2,3 | γ2 | A1a2 | ||
Granule cells | α1 | α6 | β2,3 | γ2 | δ | A6a2,A16a2,A06 |
Golgi type II cells | α1 | α3 | γ2 | |||
Motoneurons | ||||||
(Cranial nerve nuclei) | ||||||
Facial motor nucleus | ||||||
Hypoglossal nucleus | α1 | α2 | γ2 | |||
Trigeminal motor nucleus | ||||||
Ambiguus nucleus | α2 | γ2 |
↵2-a Co-expressed subunits were visualized immunohistochemically at the cellular level. The subunits analyzed here are α1, α2, α3, α5, α6, β2, β3, γ2, and δ (where the anti-β2 antibody used does not distinguish between β2 and β3, “β2,3” is noted). In each combination the subunits of that set not detected are not indicated. Where multiple isoforms of α or β co-occur, they are not necessarily combined in one receptor molecule; for all the subunits, the co-occurrences shown are within a cell not necessarily within a molecule, and sometimes are within a cell type. [The localizations are from Mohler et al. (1996b)].