Table 3

Modulators acting at the benzodiazepine (or Bz/ω) site3-a

Chemical classExamples
1,4-BenzodiazepinesDiazepam
1,5-BenzodiazepinesClobazam
2,3-BenzodiazepinesGYKI-52322
ImidazobenzodiazepinonesBretazenil; FG 8205; ZG-633-b
Imidazobenzodiazepine carboxamidesImidazenil
Heterocyclic, annelated 1,4-diazepinesBrotizolam; clotiazepam; Ro 19-4603
TriazolopyridazinesCL 218872
PyrazoloquinolinesCGS 8216; CGS 9895
QuinolinesPK 9084
ImidazoquinolinesNNC 14-05783-b; U-93631
ImidazoquinazolinesNNC 14-81983-b
BenzoquinolizonesRo 19-8022
PyrazolopyridinesCGS 20625; ICI 190622
BenzothiepinopyridazinonesY-236843-b
ThienopyrimidinesNNC 14-0590
ImidazopyridinesZolpidem
ImidazopyrimidinesDivaplon; Ru 33-203
CyclopyrrolonesZopiclone, suriclone
β-CarbolinesAbecarnil

  • ↵3-a The examples chosen are positive modulators on at least some of the GABAA receptor subtypes; some may also be negative modulators at other subtypes.

  • ↵3-b ZG-63 (Wong et al., 1993); NNC 14-0578/NNC 14-8198 (Wong et al., 1995); Y-23684 (Yasumatsu et al., 1994).