Table 12

Omeprazole inhibition of diazepam metabolism in hepatic microsomes and hepatocytes (Zomorodi and Houston, 1995)

	Pathway
	3HDZ	NDZ
Microsomal K_i (μM)^12-a	108 ± 30	226 ± 76
Hepatocyte K_i(μM)^12-b	28 ± 11	59 ± 27
Microsomal K_m/K_i	1.1	0.1
Hepatocyte K_m/K_i	2.5	0.6

↵12-a Mean ± SD, n = 4.
↵12-b Mean ± SD, n = 3.