Table 13

Gut and hepatic extraction of cyclosporine and the effects of enzyme inducers and inhibitors at the boundary conditions for absorption (Wu et al., 1995)

	F_abs	E_G	X_G	E_H	X_H
Rifampicin	100%	0.65	1.31	0.33	1.40
	86%	0.59	1.40 (X_G = X_H)
	77%	0.54	1.49
	65%	0.46	1.68
Ketoconazole	100%	0.71	0.49	0.14	0.56
	86%	0.66	0.36
	77%	0.62	0.25
	65%	0.55	Indeterminate
Erythromycin	100%	0.51	0.44	0.20	0.78
	86%	0.43	0.23
	77%	0.37	Indeterminate

F_abs, Fraction of the drug dose absorbed into and through the gastrointestinal membranes.
E_G, E_H, Gut and hepatic extraction ratio, respectively.
X_G, X_H, Changes in E_G and E_H, respectively, during coadministration of the interacting drug.