Comparison of the prediction of triazolam-ketoconazole interaction by von Moltke’s and our method
| Our method | von Moltke’s method | ||
|---|---|---|---|
| Ki(μM) | α-OH | 0.006 | 0.006 |
| 4-OH | 0.023 | 0.023 | |
| Iplasma(μM) | 8.0–9.1 | 9.32 | |
| Iliver(μM) | — | 10.4–18.9 | |
| (Kp = 1.12–2.03) | |||
| Iuliver ( = Iuplasma) (μM) | 0.080–0.091 | — | |
| Iliver/Ki | α-OH | — | 1730–3150 |
| 4-OH | — | 452–822 | |
| Iuliver/Ki | α-OH | 13–15 | — |
| 4-OH | 3.5–4.0 | — | |
| Predicted degree of inhibition | 86–87% | >95% |