Table 4
Inhibition of sparteine metabolism (CYP2D6) by coadministration of quinidine
Dose (mg)
Route
AUC (ng · hr/ml)
CL
tot
(ml/min)
control
50
p.o.
851
514
+ quinidine
2440
CL
r
(ml/min)
CL
h
(ml/min)
CL
h,m
4-a
(ml/min)
CL
h,m
/CL
tot
I
in,u
/K
i
154
360
126
0.25
13–65
↵
4-a
dehydration.