Inhibition of cyclosporin metabolism (CYP3A4) by coadministration of erythromycin
| Dose (mg) | Route | AUC (ng · hr/ml) | CLtot (ml/min/kg) | ||
|---|---|---|---|---|---|
| control | 6 | p.o. | 9720 | 3.90 | |
| + erythromycin | 15200 | ||||
| CLr(ml/min/kg) | CLh (ml/min/kg) | CLh,m 8-a(ml/min/kg) | CLh,m/CLtot | Iin,u/Ki | |
| 0.23 | 3.67 | 2.97 | 0.76 | 0.05–0.26 | |
↵8-a formation of M1, M17 and M21.