Table 10

Distinguishing pharmacological characteristics of P2 receptors

P2X receptorsDesensitizationα,β-meATP sensitivityPPADS sensitivitySuramin sensitivity
P2X1 RapidYesYesYes
P2X2 SlowYesYes
P2X3 RapidYesYesYes
P2X4 Slow
P2X5 SlowYesYes
P2X6 Slow
P2X7(P2Z)SlowN.D.Yes
P2X2P2X3 SlowYesN.D.N.D.
P2Y receptors Agonist sensitivity
2MeSATPATPUTPADPUDP
P2Y1 YesYesYes
P2Y2 YesYes
p2y3YesYesYes
P2Y4 Yes11-a Yes
P2Y6 Yes
P2Y11 YesYes
P2Y ADP 11-b Yes
Endogenous uridine nucleotide-specificYesYes
  • —, weak or inactive; N.D., not determined.

  • 11-a Rat, but not human. P2Y4 receptor is sensitive to ATP = UTP.

  • 11-b ATP is a competitive antagonist.

  • Lower case is used to designate the p2y3 receptor in recognition that it is a nonmammalian (chick) receptor and may be the homolog of the mammalian P2Y6 receptor.