Table 6

Functional distribution of endogenously expressed vascular A2adenosine receptors

Vessel and speciesReceptorLocationReference
Aorta; guinea-pigA2B EC, SM Hargreaves et al., 1991; Martin, 1992; Martin et al., 1993b; Gurden et al., 1993; Alexander et al., 1994
Aorta; rabbitA2A N.D. Balwierczaket al., 1991
Aorta; ratA2A, A2B EC, SM6-a Conti et al., 1993; Lewiset al., 1994; Monopoli et al., 1994; Prentice and Hourani, 1996
Aortic EC; humanA2A, A2B EC Iwamoto et al., 1994
Aortic SM cells; ratA2B SM Dubey et al., 1996
Coeliac artery; rabbitA2A N.D. Balwierczaket al., 1991
Coronary artery; bovineA2A N.D. Conti et al., 1993;Monopoli et al., 1994
Coronary artery; canineA2A N.D. Balwierczak et al., 1991;Gurden et al., 1993
Coronary artery; humanA2A N.D. Makujina et al., 1992
Coronary artery; porcineA2A, A2(B) EC, SM Balwierczak et al., 1991; Abebe et al., 1994; Monopoli et al., 1994
Coronary artery EC; guinea-pigA2A EC Schiele and Schwabe, 1994
Coronary bed/vessels; guinea-pigA2A EC, SM Martinet al., 1993b; Vials and Burnstock, 1993
Corpus cavernosum; rabbitA2B EC, SM Chiang et al., 1994
DDT1 MF-2 cells (SM cells)A2A SM Ramkumar et al., 1991
Hepatic arterial bed; rabbitA2A N.D. Mathieet al., 1991a,b
Mammary artery; humanA2A N.D. Makujina et al., 1992
Mesenteric arterial bed; ratA2A EC, SM Hileyet al., 1995
Mesenteric arterial bed; ratA2B SM Rubino et al., 1995
Mesenteric artery; rabbitA2A N.D. Balwierczaket al., 1991
Placental arterial bed; humanA2A N.D. Read et al., 1993
Pulmonary artery; guinea pigA2B SM Szentmiklósi et al., 1995
Pulmonary arterial bed; ratA2B SM Haynes et al., 1995
Pulmonary artery and vein; rabbitA2 EC, SM Steinhorn et al., 1994
Pulmonary arterial bed; rabbitA2 N.D. Pearl, 1994
Renal artery; ratA2B EC Martin and Potts, 1994
Renal bed; ratA2A SM Levens et al., 1991a,b; Agmon et al., 1993
Saphenous vein; canineA2B N.D. Hargreaves et al., 1991
Saphenous vein; humanA2A N.D. Makujina et al., 1992
Umbilical vein EC; humanA2A EC Sobrevia et al., 1997
  • EC, endothelium; SM, smooth muscle; N.D., not determined.

  • 6-a A2A adenosine receptor only.