Table 1

Functions of Hsp families

FamilyMajor functionsReferences
Hsp100Protein disaggregation, thermotolerance Schirmer et al., 1996
Hsp90Regulatory interactions with signaling proteins, stabilization of misfolded proteins Csermely et al., 1998
Hsp70Protein folding, membrane transport of proteins Hartl, 1996
Hsp60Protein folding (limited substrates in eukaryotic cytoplasm) Hartl, 1996; Buchner, 1996
Hsp40Protein folding, co-chaperone for Hsp70 Cyr, 1997
Small HspStabilization of misfolded proteins, thermotolerance, eye lens structural proteins Buchner, 1996