Receptor | pS | % | pS | % | pS | % | References |
---|---|---|---|---|---|---|---|
GluR2flip6-a 6-b | 0.4 | Swanson et al., 1997b | |||||
GluR4flip6-b | 24 | 8 | 15 | 18 | 8 | 74 | Swanson et al., 1997b |
GluR4flip/GluR2 | 10 | 8 | 4 | 92 | Swanson et al., 1997b | ||
GluR5(R)6-b - 6-d | 0.2 | Swanson et al., 1996 | |||||
GluR5(R)/KA26-d | 1.0 | Swanson et al., 1996 | |||||
GluR5(Q)6-b 6-d | 14 | 12 | 9 | 67 | 5 | 21 | Swanson et al., 1996 |
GluR5(Q)/KA26-d | 17 | 5 | 9 | 18 | 5 | 77 | Swanson et al., 1996 |
GluR6(R)6-b 6-d 6-e | 0.35 | Howe, 1996; Swanson et al., 1996; Traynelis and Wahl, 1997 | |||||
GluR6(R)/KA26-d 6-e | 0.65 | Howe, 1996; Swanson et al., 1996 | |||||
GluR6(Q)6-b 6-d | 25 | 4 | 15 | 15 | 8 | 81 | Swanson et al., 1996 |
GluR6(Q)/KA26-d | 20 | 6 | 12 | 20 | 7 | 74 | Swanson et al., 1996 |
NR1-1a/NR2A | 51 | 77 | 38 | 23 | Stern et al., 1992, 1994 | ||
NR1-1a/NR2B | 51 | 83 | 39 | 17 | Stern et al., 1992 | ||
NR1-1a/NR2C | 36 | 75 | 19 | 25 | Stern et al., 1992 | ||
NR1-1a/NR2D | 35 | 61 | 17 | 39 | Wyllie et al., 1996 | ||
NR1-1a/NR2A/N | 75 | ND | 35 | ND | Das et al., 1998 |
The three largest slope or chord single-channel conductance levels are shown for steady-state activation of recombinant glutamate receptors. Unless stated otherwise, glutamate (GluR1-6) or glutamate plus glycine (NR1/NR2A-D) were applied and responses were recorded in 0.85 to 1.0 mM external Ca2+. The relative proportion of openings to each level is indicated as percent. ND, not determined.
↵6-a Similar results were obtained for both GluR2flip and GluR2flop.
↵6-b Homomeric receptors.
6-c Receptors were pretreated with concanavalin A.
↵6-d Receptors were activated by domoate.
↵6-e Receptors were activated by kainate; conductance was determined by variance analysis.
6-f Channel openings were recorded nM levels of extracellular Ca2+; conductance levels may arise from separate channels.