Year | Observation | References |
---|---|---|
1974 | Glycine enhancement of cGMP in the cerebellum is strychnine independent | Mao et al., 1974 |
1978 | [3H]Glycine binding is only partially strychnine sensitive | DeFeudis et al., 1978 |
1978 | HA-966 attenuates excitatory amino acid responses in isolated spinal cord of frogs and immature rats | Biscoe et al., 1978 |
1979 | Glycine enhances K+-stimulated dopamine release in striatal prisms in a strychnine-insensitive manner | Martin and Mitchell, 1979 |
1981 | Strychnine-insensitive binding sites for [3H]glycine are distributed mainly in forebrain areas and inhibited by d-amino acids | Kishimotoet al., 1981 |
1986 | Receptor autoradiography shows that strychnine-insensitive [3H]glycine binding predominates in the forebrain and cerebellum, whereas [3H]strychnine labels lower brain areas (e.g., medulla oblongata) | Bristow et al., 1986 |
1987 | Glycine enhances NMDA responses in patch-clamp studies in cortical neurons in a strychnine-insensitive manner | Johnson and Ascher, 1987 |
1987 | Glycine enhances binding of NMDA channel blockers in a strychnine-insensitive manner | Bonhauset al., 1987; Reynolds et al., 1987; Snellet al., 1987; Wong et al., 1987 |
1987 | In vivo, glycine enhances NMDA-stimulated cGMP synthesis in mouse and rat cerebellum; its recognition site is not saturated | Danysz et al., 1987, 1989c |
1987 | Glycine enhances NMDA receptor-mediated EPSPs in cultured neurons | Forsythe et al., 1987, 1988 |
1987 | Kynurenic acid is found to be the first glycineB, site antagonist (not very selective) | Kessleret al., 1987, 1989b |
1988 | CNQX1-a and DNQX are nonselective glycine site antagonists | Birch et al.,1988a,b |
1988 | Glycine enhances the affinity of [3H]glutamate | Nguyen et al., 1987; Faddaet al., 1988 |
1988 | HA-966 attenuates NMDA responses by acting at the glycine site | Fletcher and Lodge, 1988 |
1988 | 7-Cl-KYN is introduced as the first selective full antagonist of the glycine site; HA-966 is a partial agonist | Kempet al., 1988a,b |
1988 | Occupation of the glycine site is necessary for the activation of NMDA receptors (coagonist concept) | Kleckner and Dingledine, 1988 |
1988 | In vivo, glycine potentiates strychnine-induced convulsions by acting through the NMDA receptor | Larson and Beitz, 1988 |
1989 | Glycine inhibits desensitization of NMDA receptors | Mayer et al., 1989a |
1989 | In vivo, d-serine excites some thalamic neurons in a strychnine-insensitive manner; its recognition site is not saturated | Salt, 1989 |
1989 | In vivo, d-serine enhances NMDA-stimulated cGMP synthesis in mice and rat cerebellum; its recognition site is not saturated | Wood et al., 1989 |
1989 | d-Serine enhances Ca2+ influx induced by NMDA in cultures of cerebellar granule cells | Wroblewski et al., 1989 |
1993 | d-Serine is present in the CNS and might be an endogenous agonist at the strychnine-insensitive glycine site | Hashimoto et al., 1993c |
1994 | The glycine recognition site is located on the NR1 subunit | Kuryatovet al., 1994 |
1997 | GLYT1 uptake can very efficiently regulate local glycine levels | Supplisson and Bergman, 1997 |
↵1-a CNQX, 6-cyano-7-nitroquinoxaline-2,3-dione.