Compilation of in vivo studies showing effects of glycineB site agonists or partial agonists, indicating that the glycineBsites are not saturated
| Effect | Agents used (route of administration) | References |
|---|---|---|
| Analgesia after unilateral ligation of sciatic nerve | Glycine (intrathecal) | Simpson et al., 1997 |
| Enhancement of tail flick response | d-Serine (intrathecal) | Kolhekaret al., 1994 |
| Anxiogenic response | d-Serine, glycine (PAG)7-a | Schmittet al., 1995 |
| Pressor responses | Glycine,d-serine (caudal ventrolateral medulla) | Kapoor et al., 1996 |
| Enhancement of NMDA-induced hypertension | Glycine (PAG) | Berrino et al., 1992 |
| Enhancement of NMDA receptor-dependent cGMP stimulation in the cerebellum | Glycine (systemic, cisterna magna) | Danysz et al., 1987, 1989c |
| Enhancement of cGMP production in the cerebellum | d-Cycloserine (i.p.) (at high doses, antagonism), d-serine (i.p.) | Wood et al.,1989; Emmett et al., 1991 |
| Enhancement of NMDA-induced elevation of cGMP in the cerebellum | d-Serine (local, microdialysis) | Vallebuona and Raiteri, 1995; Fedele et al., 1997 |
| Enhancement of cGMP production in the hippocampus | d-Serine (local, microdialysis) | Uckeleet al., 1989 |
| Enhancement of NMDA-induced convulsions in rats at postnatal day 7 | d-Serine (i.p.) | Peeters and Vanderheyden, 1992 |
| Enhancement of NMDA-induced convulsions | d-Serine (i.c.v.) | Singh et al., 1990c, 1991 |
| Potentiation of strychnine-induced convulsions | Glycine; AP5-sensitive (intrathecal) | Larson and Beitz, 1988 |
| Depression of positive waves in the hippocampus; electrophoresis | Glycine (local) | Erdemli et al., 1990 |
| Enhancement of NMDA responses in the spinal cord and dorsal horn; electrophoresis | Glycine (local) | Budai et al., 1992 |
| Enhancement of NMDA responses in the cerebellum; electrophoresis (dependent on the firing rate) | Glycine (local) | Netzeband et al., 1990 |
| Enhancement of NMDA responses in the visual cortex; electrophoresis | d-Serine (local) | Czepita et al., 1996 |
| Enhancement of NMDA responses in the red nucleus; electrophoresis | Glycine, d-serine (local) | Goldsteinet al., 1989 |
| Enhancement of NMDA responses; electrophoresis | Glycine, d-serine (red nucleus) | Goldstein et al., 1989 |
| Enhancement of field potential in hippocampus (DG) | d-Cycloserine (local) | Pitkanen et al., 1994 |
| Enhancement of field potential in DG | d-Cycloserine (hippocampus) | |
| Enhancement of NMDA-induced negative field potential in the hippocampus (CA1); electrophoresis | Glycine (local) | Dalkaraet al., 1992 |
| Enhancement of synaptic responses in the red nucleus; electrophoresis | d-Serine (local), glycine produced inhibition | Davies et al., 1994 |
| Enhancement of eye blink response learning | d-Cycloserine, monoclonal antibody to glycine site | Thompson et al., 1992 |
| Enhancement of LTP in CA1 | d-Serine (hippocampus) | Thiels et al., 1992 |
| Enhancement of spatial learning | d-Cycloserine (i.p.) | Monahanet al., 1989b; Sirvio et al., 1992; Baxteret al., 1994; Zajaczkowski and Danysz, 1997 |
| Improvement in word recall test in humans | d-Cycloserine (subcutaneous) | Wesnes et al., 1991 |
| Enhancement of LTP in the hippocampus (CA1) in microcephalic rats | d-Serine (local) | Ramakers et al., 1993 |
| Attenuation of PCP-induced hyperlocomotion | d-Serine,d-alanine (i.c.v.) | Tanii et al., 1991, 1994 |
| Attenuation of (+)MK-801 and PCP stereotypy | d-Serine, glycine (i.c.v.) | Contreras, 1990 |
| Attenuation of PCP-induced hyperlocomotion | Glycine (i.p.) | Toth and Lajtha, 1986 |
| Enhancement of noradrenaline release in the red nucleus of stria terminalis | d-Serine (local) | Aliaga et al., 1995 |
| Enhancement of NMDA-stimulated dopamine release in the striatum | Glycine (local), microdialysis | Krebs et al., 1989; Martinez-Fong et al., 1992 |
| Enhancement of NMDA-stimulated glutamate release in the striatum | d-Serine (local), microdialysis | Bustoset al., 1992 |
| Enhancement of ischemia-induced damage | Glycine, serine (i.c.v.) | Dalkara et al.,1990 |
↵7-a PAG, periaqueductal gray; DG, dorsal ganglia.