Parameters of [3H]RTX binding to VRs in the rat
| Tissue | RTX | Cooperativity Index | Capsaicin | Capsazepine |
|---|---|---|---|---|
| Kd; pM | Ki, nM | Ki, nM | ||
| DRG (membranes) (1–3) | 18–46 | 1.7–1.8 | 600–4,900 | 3,500–3,900 |
| DRG (isolated neurons) (4) | 48 | 1.8 | 2,100 | 3,200 |
| Spinal cord (1, 3, 5) | 13–31 | 1.9–2.3 | 300–5,400 | 3,300–4,000 |
| Sciatic nerve (1) | 46 | 2.0 | 4,700 | 3,400 |
| Urinary bladder (1, 4, 6, 7) | 30–87 | 1.0–1.9 | 500–3,700 | 4,800–5,000 |
| Urethra (8) | 105 | 1.0 | N.D. | N.D. |
| Trachea and main bronchi (5) | 250 | 1.1 | 100 | 100 |
| Colon (9) | 3,000 | 1.0 | 3,000 | 100 |
| Vagal nerve (1) | 45 | 2.3 | N.D. | N.D. |
| Dorsal vagal complex (1) | 28 | 2.6 | N.D. | N.D. |
References indicated in parentheses: (1) Ács et al., 1994a; (2) Szallasi and Blumberg, 1993a; (3) Szallasi et al., 1993a; (4)Ács et al., 1996b; (5) Szallasi et al., 1993b; (6) Szallasi et al., 1993c; (7) Szallasi et al., 1993d; (8) Parlani et al., 1993; (9)Goso et al., 1993a.