Biochemical pharmacology of VRs
| Receptor family | TRP family of store-operated calcium channels |
| Cloned member | VR1 (rat) |
| Signal transduction | non-selective cation channel |
| Size | 95 kDa (cloned VR1); 300 kDa (radiation inactivation size) |
| Typical natural agonists | RTX, capsaicin, isovelleral, scutigeral |
| Other activators | low pH, noxious heat |
| Endogenous activators | low pH (?) |
| Antagonists | capsazepine (competitive); ruthenium red (functional) |