Changes in selected markers (neuropeptides, enzymes, receptors) of rat primary sensory neurons following RTX (single s.c. dose) or capsaicin (cumulative s.c. dose) treatment as well as axotomy
| Capsaicin | RTX | Axotomy | |
|---|---|---|---|
| Neuropeptides | |||
| VIP | Depleted | Up-regulated | Up-regulated |
| Galanin | Depleted | Up-regulated | Up-regulated |
| CGRP | Depleted | No major changes | Depleted |
| CCK | Depleted | No major changes | Up-regulated |
| Somatostatin | Depleted | No major changes | Depleted |
| SP | Depleted | Depleted | Depleted |
| Neuronal enzyme | |||
| NOS | Up-regulated | Up-regulated | Up-regulated |
| Receptors | |||
| CCK-B | Depleted | Up-regulated | Up-regulated |
| C-type VR | Depleted | Depleted | Depleted |
| R-type VR | Depleted | Depleted | No major changes |
Resiniferatoxin (300–500 μg/kg) was given s.c. into the scruff of the neck of adult Sprague-Dawley rats. Capsaicin was administered in high, cumulative doses. A typical protocol includes one daily treatment with increasing doses on 5 consecutive days to achieve a total dose of 950 mg/kg. See SectionVIII.B.5 and B.6 for details and references.