Table 10

Toxicities associated with free and L-DOX

ToxicityEffect of Liposome Encapsulation
Cardiac toxicityReduced or not observed
MyelosuppressionReduced (to a greater extent with SSLs)
MucositisSlightly increased with Doxil
AlopeciaReduced or not observed
Severe local tissue necrosis after drug extravasationReduced
Nausea and vomitingReduced or not observed
H-F syndromeObserved with Doxil or with continuous infusion of free DOX