Table 1

Commercial liposome formulations of anthracyclines

DrugManufacturerActive IngredientSizeLipid CompositionDrug/Lipid
nm w/w
Doxil (CAELYX)1-a Alza Corporation1-b DOX100HSPC/Chol/PEG-DSPE (56:39:5)0.125:1
DaunoXomeNexstar PharmaceuticalsDaunorubicin45DSPC/Chol (2:1)0.079:1
EVACET (TLC D-99)1-c The Liposome Company, Inc.DOX150eggPC/chol (55:45)0.250:1

  • ↵1-a Doxil (DOX) is known as CAELYX in Europe.

  • ↵1-b Originally developed by Sequus Pharmaceuticals, Inc.

  • ↵1-c EVACET was previously known as TLC D-99.