Animal Model | Formulation | Dose | T_{1/2} | AUC | V_{d} | CL |
---|---|---|---|---|---|---|
mg/kg | h | mg ∗ l/h | ml | ml/h | ||
Rats^{3-a} | SSL DOX | 1.0 | T _{1} = 1.8 | 683 | 13 | 0.4 |
T _{2} = 23.6 | ||||||
Free DOX | 0.9 | T _{1} = 0.16 | 11.1 | 1,014 | 24.3 | |
T _{2} = 29.1 | ||||||
Male Sprague-Dawley rats^{3-b} | HSPC/Chol/PEG-DSPE (37:20:3) | 6.0 | T _{1} = 2.8 | 2,769 | 18 | 0.5 |
T _{2} = 22 | ||||||
Free epirubicin | 6.0 | 0.23 | 15 | 3,700 | 111 | |
Rabbits^{3-a} | SSL DOX | 1.0 | T _{1} = 0.5 | 368 | 176 | 6 |
T _{2} = 21.3 | ||||||
Free DOX | 1.0 | T _{1} = 0.03 | 1 | 13,651 | 2,536 | |
T _{2} = 4.07 | ||||||
Dogs^{3-a} ^{3-c} | SSL DOX | 1.5 | T _{1} = 0.20 | 656 | 596 | 15.5 |
T _{2} = 25.9 | ||||||
SSL DOX | 0.5 | 27 ± 5 | 304 ± 118 | 1000 ± 100 | 25.2 ± 7.2 |