Table 4

Pharmacological profile of 5-HT terminal autoreceptors in cortex and hippocampus of different species as determined by their effect on 5-HT release

SpeciesAgonistsAntagonistsReference
Cortex
 Rat5-CT = RU 24969 > 5-HT >>> 8-OH-DPATmethio. > meterg. Limberger et al., 1991
5-HT(±)-cyanop. < (−)-alprenolol < (−)-pind. < (−)-oxprenolol Middlemiss, 1986
(−)-prop. Middlemiss, 1984
(−)-penbutolol Hjorth and Sharp, 1993
5-CT > 5-HT > 5-MeOT > LSD(−)-cyanop. > (±)-cyanop. > methio. > (+)-cyanop. > (±)-prop. > (−)-pind. > meterg. > quipazinel Engel et al., 1986
(±)-cyanop. < methio. < (−)-prop. < (−)-pind. Schlicker et al., 1985
 Pig5-HT > 5-MeOT > RU 24969 ≫ 8-OH-DPATmethio. > meterg. ≫ mianserin > prop. > mesulergine Schlicker et al., 1989
 Guinea pig5-CT > 5-HT > RU 24969methio. > meterg. >>> prop. Limberger et al., 1991
sumatriptan Sleight et al., 1990
5-CT > 5-HTmeterg. Ormandy, 1993
5-MeOT > sumatriptan
L694247 Beer et al., 1993
5-CT > 5-HT > sumatriptanmethio. Wilkinson and Middlemiss, 1992
5-CT > 5-MeOT Blier and Bouchard, 1994
5-MeOT > sumatriptanmethio. > meterg. ≫ methysergide Middlemiss et al., 1988
GR 127935 El Mansari and Blier, 1996
GR 127935 > methio. Price et al., 1994
 Rabbit5-CT > 5-HT > RU 24969methio. > meterg. >>> prop. Limberger et al., 1991
 HumanRU 24969 > 5-CTmethio. > methysergide > meterg. = prop. Galzin et al., 1992
5-HT > sumatriptanmethio. > meterg. Maura et al., 1993
Hippocampus
 RatRU 24969 < 5-HTmethio. > (−)-prop. Maura et al., 1986
RU 24969 > CP 93129methio. Hjorth and Tao, 1991
 Guinea pig5-HT > sumatriptanmethio. Wilkinson et al., 1993
5-CT > 5-MeOT Blier and Bouchard, 1994
 Rabbit5-CT > 5-HT > 5-MeOT >>> 8-OH-DPATmeterg. > cyanop. > methio. Feuerstein et al., 1987
  • Within each species drugs have been placed in a visual analog scale (decreasing affinity to the right). cyanop., cyanop indolol; methio., methiothepin; prop., propranolol; pind., pindolol; meterg., metergoline.