Table 5

Tissue distribution of DOX in animals treated with L-DOX

Animal ModelLiposome FormulationTimeDose5-aPlasmaSpleenLiverSkinHeartLungKidney
h mg/kg μg/ml μg/g
Nude mice (N87 tumor implants)5-b HSPC/Chol/PEG-PE (92.5:70:7.5)721012.89 15.84  ± 1.585.36  ± 0.352.37  ± 0.46
Rats5-c HSPC/Chol/PEG-PE (56.4:38.3:5.3)2417.18  ± 1.411.27  ± 0.110.46  ± 1.11.67  ± 0.551.59  ± 0.331.70  ± 0.11
Free DOX0.512.56  ± 0.331.67  ± 0.160.46  ± 0.062.21  ± 0.172.71  ± 0.493.61  ± 0.40
Female CD1 mice5-d eggPC/Chol (55:45) 200 nm52014.3  ± 3.8995.1  ± 284.7134  ± 20.24.1  ± 2.216.5  ± 4.117.3  ± 6.2
DSPC/Chol (55:45) 230 nm52027.4  ± 3.2832.2  ± 64.8137.5  ± 10.72.4  ± 1.211.4  ± 3.413.1  ± 2.1
Free DOX5200.09  ± 0.0439.0  ± 8.325.8  ± 3.715.5  ± 3.429.9  ± 5.835.5  ± 7.9
Female BDF1 mice5-e DSPC/Chol (55:45) (100 nm) C max 10140.5  ± 5.3259.8  ± 7.868.7  ± 3.77.8  ± 1.530.9  ± 0.6
Free DOX C max 7.52.7  ± 0.313.5  ± 1.459.5  ± 2.435.1  ± 1.898.5  ± 6.4
  • C max is the peak concentration of drug achieved, and it varied as a function of time.

  • 5-a Dose is given in mg/kg DOX.

  • 5-b Gabizon et al. (1997).

  • 5-c Working and Dayan (1996).

  • 5-d Mayer et al. (1989).

  • 5-e Krishna and Mayer (1997).

  • Errors are provided where available.