Table 6

Tissue AUC values after i.v. administration of various liposomal and free drugs

Animal Model	Liposome Formulation	Dose^6-a	Plasma	Tumor	Spleen	Liver	Heart	Lung	Kidney
		mg/kg	μg · h/ml	μg · h/g
BALB/c mice with C26 colon carcinoma^6-b ^6-d	DSPC/Chol/GM₁(2:1:0.2)	^6-c		662.2	1974	1299	83.25	141.5	241.8
	DSPC/Chol (2:1)	^6-c		256.2	3348	1757	31.98	28.3	40.48
Female BDF1 mice^6-e	DSPC/Chol (55:45)	10	1095.2	470.6	8923.8	2444.5	67		1265.6
	Free DOX	7.5	1.3	73.8	496.9	874.9	820.4		1258.1
BALB/c mice with colon C26 carcinoma^6-f	PEG-PE/DSPC/Chol (6:47:47)	5	809.5	169.6	320.3	309.4	41.9	91.4	132.0
	DSPC/Chol (1:1)	5	342.8	50.1	365.5	341.4	41.2	67.5	72.4
	Free DOX	5	1	18.1	178.1	168.8	63.2	106.4	146.1
BALB/c mice with P1798 lymphosarcoma^6-g	DSPC/Chol (2:1) (62 nm)	20	2275.6	2470.5	3596.2	693.6	265.1	685.0	1237.2
	Free daunorubicin	20	10	245.1	2213.4	335.5	249.9	612.2	976.8
BDF₁ mice^6-h(mitoxantrone)	DSPC/Chol	10	1970		12630	4832		178	751
	DSPC/Chol/PEG-PE	10	4863		7242	4302		218	697

AUC was calculated from either 0–96 h,^d 1–24 h,^f by the trapezoidal rule,^e, h or 0–48 h.^g
↵6-a Dose is given in mg/kg DOX.
↵6-b Data were collected using encapsulated ⁶⁷Ga as the tracer. The tissue distribution is expressed as percent of injected dose per gram of tissue versus time (h).
↵6-c 10–15 μmol of phospholipid/kg.
↵6-d Huang et al. (1992). Data were collected using encapsulated⁶⁷Ga as the tracer. The tissue distribution is expressed as percent of injected dose per gram of tissue versus time (h) after injection.
↵6-e Krishna and Mayer (1997).
↵6-f Unezaki et al. (1995).
↵6-g Forssen et al. (1992).
↵6-h Chang et al. (1997).