Table 6

Differential influence of species and stimulation paradigm on the effects of terminal autoreceptor antagonists on 5-HT release in cortex and hippocampus

SpeciesAntagonistEffect ObservedStimulation Procedure UsedReference
Cortex
 Rat(−)-Alprenolol (1 μM)K+25 mM Middlemiss, 1986
(−)-Atenolol (1 μM)◂–▸K+25 mM Middlemiss, 1986
(±)-Cyanopindolol (10–100 nM)K+25 mM Middlemiss, 1986
(±)-Cyanopindolol (10 nM)3 Hz; 360 pulses Schlicker et al., 1985
Isamoltane (1 μM)100 Hz; 4 pulses Limberger et al., 1991
Mesulergine (1 μM)◂–▸K+25 mM Middlemiss et al., 1988
Metergoline (1 μM)◂–▸3 Hz; 360 pulses Göthert, 1980
Metergoline (100 nM)100 Hz; 4 pulses Limberger et al., 1991
Methiothepin (1 μM)K+25 mM Middlemiss, 1984
Methiothepin (100 nM)3 Hz; 360 pulses Göthert, 1980
Methiothepin (100 nM)◂–▸100 Hz; 4 pulses Limberger et al., 1991
Methysergide (1 μM)◂–▸K+25 mM Middlemiss et al., 1988
(−)-Oxprenolol (1 μM)K+25 mM Middlemiss, 1986
(+)-Oxprenolol (1 μM)K+25 mM Middlemiss, 1986
(−)-Pindolol (1 μM)◂–▸K+25 mM Middlemiss, 1986
(−)-Propranolol (1 μM)◂–▸K+25 mM Middlemiss, 1984
(−)-Propranolol (1 μM)100 Hz; 4 pulses Limberger et al., 1991
Quipazinel (10 μM)K+ 25 mM Middlemiss, 1984
 Guinea pig(±)-Cyanopindolol (1 μM)◂–▸K+25 mM Middlemiss et al., 1988
GR 127935 (10 μ)Spontaneous release, freely movingRoberts et al., 1994
GR 127935 (100 nM)Spontaneous release, anesthesized Skingle et al., 1995
Isamoltane (1 μM)100 Hz; 4 pulses Limberger et al., 1991
Mesulergine (1 μM)◂–▸K+25 mM Middlemiss et al., 1988
Metergoline (300 nM)◂–▸
Metergoline (1 μM)100 Hz; 4 pulses Limberger et al., 1991
Methiothepin (10 nM)◂–▸K+ 25 mM Middlemiss et al., 1988
Methiothepin (300 nM) Wilkinson et al., 1993
Methiothepin (1 μM)◂–▸100 Hz; 4 pulses Limberger et al., 1991
Methysergide (1 μM)K+25 mM Middlemiss et al., 1988
(−)-Propranolol (1 μM)◂–▸100 Hz; 4 pulses Limberger et al., 1991
 RabbitIsamoltane (1 μM)100 Hz; 4 pulses Limberger et al., 1991
Metergoline (100 nM)100 Hz; 4 pulses Limberger et al., 1991
Methiothepin (1 μM)◂–▸100 Hz; 4 pulses Limberger et al., 1991
(−)-Propranolol (1 μM)◂–▸100 Hz; 4 pulses Limberger et al., 1991
Hippocampus
 RatBMY 7378 (0.25 mg/kg i.v.)0.5 or 1 Hz; 60 or 120 pulses anesthesized Chaput and de Montigny, 1988
(±)-Cyanopindolol (10 nM–μM)3 Hz; 360 pulses Feuerstein et al., 1987
(±)-Cyanopindolol (30–300 nM)K+15 mM Maura et al., 1987
(±)-Cyanopindolol (10–100 nM) + nitroquipazine (1 μM)3 Hz; 360 pulses Feuerstein et al., 1987
(±)-Cyanopindolol (10 nM–1 μM) + fluvoxamine (1 μM)3 Hz; 360 pulses Feuerstein et al., 1987
Mesulergine (300 nM)◂–▸K+ 15 mM Maura et al., 1986
Metergoline (1 mg/kg i.v.)1 Hz; 120 pulses Haddjeri et al., 1996
Methiothepin (30–300 nM)◂–▸K+ 15 mM Maura et al., 1986
Methiothepin (1 mg/kg i.v.)5 Hz; 600 pulses anesthesized Chaput et al., 1986a,b
Methiothepin (1 mg/kg i.v.)1 Hz; 120 pulses anesthesized Chaput et al., 1986a,b
Methiothepin (3 μM)K+30 mM Auerbach et al., 1990
Methiothepin (10 μM)Spontaneous release anesthesized Hjörth and Tao, 1991
Methysergide (300 nM)◂–▸K+ 15 mM Maura et al., 1986
(−)-Penbutolol (1 μM) + citalopram (5 mg/kg s.c.)◂–▸Spontaneous release anesthesized Hjörth, 1993
(−)-Propranolol (300 nM)◂–▸K+ 15 mM Maura et al., 1986, 1987
 Guinea pigMethiothepin (300 nM–1 μM)1 Hz; 120 pulses Wilkinson and Middlemiss, 1992
 Rabbit(±)-Cyanopindolol (10 nM–1 μM)3 Hz; 360 pulses Feuerstein et al., 1987
(±)-Cyanopindolol (10 nM–1 μM) + nitroquipazine (1 μM)3 Hz; 360 pulses Feuerstein et al., 1987
(±)-Cyanopindolol (10 nM–1 μM) + fluvoxamine (1 μM)3 Hz; 360 pulses Feuerstein et al., 1987
Metergoline (10 nM–1 μM)◂–▸3 Hz; 360 pulses Feuerstein et al., 1987
Metergoline (10 nM–1 μM) + nitroquipazine (1 μM)3 Hz; 360 pulses Feuerstein et al., 1987
Metergoline (10 nM–1 μM) + fluvoxamine (1 μM)3 Hz; 360 pulses Feuerstein et al., 1987
Methiothepin (10 nM–1 μM)3 Hz; 360 pulses Feuerstein et al., 1987
Methiothepin (10 nM–1 μM) + nitroquipazine (1 μM)3 Hz; 360 pulses Feuerstein et al., 1987
Methiothepin (10 nM–1 μM) + fluvoxamine (1 μM)3 Hz; 360 pulses Feuerstein et al., 1987
Methysergide (10 nM–1 μM)3 Hz; 360 pulses Feuerstein et al., 1987
(−)-Propranolol (10 nM–1 μM)◂–▸3 Hz; 360 pulses Feuerstein et al., 1987