Table 7

Compounds that allow a pharmacological distinction between 5-HT1B and 5-HT1D receptors

CompoundLog DifferenceReference
Compounds with higher affinity for rodent 5-HT1B than 5-HT1D/non-rodent 5-HT1B receptors (difference in affinity stated in log units)
 (−)-SDZ 21009>3 Hoyer et al., 1985;Hoyer and Schoeffter, 1991
 CP93129>2 Bruinvels et al., 1991; Koe et al., 1992
 (−)-Pindolol>1.9 Hoyer et al., 1985; Heuring et al., 1987; Hoyer and Schoeftter, 1991
 Cyanopindolol>1.8 Engel et al., 1986; Hoyer and Schoeffter 1991
 (−)-Propranolol>1.8 Hoyer et al., 1985;Heuring et al., 1987; Hoyer and Schoeffter, 1991
Compounds with higher affinity for 5-HT1D/non-rodent 5-HT1B than rodent 5-HT1B receptors (difference in affinity stated in log units)
 Yohimbine>1.8 Heuring et al., 1987; Bruinvels et al., 1991; Hoyer and Schoeffter, 1991
 Sumatriptan>1.5 Van Wijngaarden et al., 1990; Bruinvels et al., 1991
 Mianserin>1.5 Hoyer et al., 1985; Peroutka et al., 1986;Heuring et al., 1987; Bruinvels et al., 1991; Hoyer and Schoeffter, 1991
 8-OH-DPAT>1.5 Heuring et al., 1987; Van Wijngaarden et al., 1990; Bruinvels et al., 1991; Hoyer and Schoeffter, 1991