Entacapone Studies10-a | Tolcapone Studies10-b | ||||
---|---|---|---|---|---|
Entacapone (n = 406) | Placebo (n = 296) | Tolcapone 100 mg t.i.d. (n = 296) | Tolcapone 200 mg t.i.d. (n = 298) | Placebo (n = 298) | |
% of patients | |||||
Dyskinesia | 27.3 | 13.9 | 41.9 | 51.3 | 19.8 |
Nausea | 11.1 | 6.4 | 30.4 | 34.9 | 17.8 |
Insomnia | 4.4 | 3.7 | 23.6 | 24.8 | 18.1 |
Anorexia | <2 | <2 | 18.9 | 22.8 | 12.8 |
Dystonia | 2.7 | 2.4 | 18.6 | 22.1 | 17.1 |
Diarrhea | 8.4 | 3.0 | 15.5 | 18.1 | 7.7 |
Dizziness | 7.4 | 5.4 | 13.2 | 6.4 | 9.7 |
Urine discoloration | 12.6 | 0 | 2.4 | 7.4 | 0.7 |
Hallucination | 3.4 | 2.4 | 8.4 | 10.4 | 5.4 |
Vomiting | <2 | <2 | 8.4 | 9.7 | 3.7 |