Table 4

Pharmacokinetics of COMT inhibitors in healthy subjects after intravenous administration

Entacapone4-a (20–25 mg)Nitecapone4-b (9.6–10 mg)Tolcapone4-c (50 mg)
T ½β(h)0.4–0.50.7–0.81.1–1.3
V ss (l)19.9–29.27.7–8.08.6–8.8
Clearance (liters/h)45.0–51.817.0–20.47.1–8.3
Free fraction (%)230.1

  • ↵4-a Heikkinen et al., 1994; Keränen et al., 1994.

  • ↵4-b Pentikäinen et al., 1989, 1990.

  • ↵4-c Jorga et al., 1998a,c.

  • Values are means.