Parameter | Entacapone5-a | Nitecapone5-b | Tolcapone5-c | ||
---|---|---|---|---|---|
100 mg | 200 mg | 100 mg | 100 mg | 200 mg | |
T max | No change | No change | No change | No change | No change |
C max | No change | No change | No change | No change | No change |
AUC ofl-dopa | +29% | +42% | +20% | +50% | +88% |
T ½ of l-dopa | No change | No change | N.A. | +32% | +60% |
AUC of 3-OMD | −35% | −46% | −48% | −64% | −64% |
AUC of DOPAC | +149% | +214% | +120% | +175% | +253% |
AUC of HVA | No change | No change | −37% | −52% | −54% |