Table 8

Clinical efficacy of entacapone and tolcapone in single-dose studies (“levodopa test”) in patients with PD

COMT Inhibitor	Patients	Dose	Method	Increase in ON Time	Increase in ON Time	Reference
	n	mg		min	%
Entacapone	19	200	Motor UPDRS	33	21	Ruottinen and Rinne, 1996a
			Tapping test	62	81
	12	200	Tapping test	35	27	Merello et al., 1994
	13	200	Tapping test	36	40	Nutt et al., 1994
	8		Walking test	72	75
	12	200	Motor UPDRS	54	39	Ruottinen and Rinne, 1996b
Tolcapone	5–10	100	Motor	54	69	Roberts et al., 1993a
		200	UPDRS	15	15
	4–9	100	Motor	62	42	Davis et al., 1995b
		200	UPDRS	51	38
	10	200	Motor UPDRS	62	65	Limousin et al., 1995