Effect of entacapone and tolcapone on AUC of 3-OMD in patients with PD
| COMT Inhibitor | Dose/Day | Treatment Duration | Decrease in 3-OMD AUC | Reference |
|---|---|---|---|---|
| mg | % | |||
| Entacapone | 600–800 | 1 wk | 44 | Kaakkola et al., 1994b |
| 800–1200 | 4 wk | 45 | Ruottinen and Rinne, 1996b | |
| 800–2000 | 4 wk | 63 | Ruottinen and Rinne, 1996c | |
| 1200 | 2 mo | 59 | Nutt et al., 1994 | |
| 800–2000 | 6 mo | 58 | Parkinson Study Group, 1997 | |
| Tolcapone | 300 | 6 wk | 66 | Davis et al., 1997 |
| 600 | 6 wk | 79 | Davis et al., 1997 | |
| 600 | 7–8 wk | 79 | Yamamoto et al., 1997 |